Journal article
Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells
K Sek, CW Chan, PA Beavis, PK Darcy
Cancer Cell | Published : 2021
Abstract
In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFNα/β production.
Grants
Awarded by Victorian Cancer Agency
Funding Acknowledgements
The authors wish to acknowledge funding support from the National Health and Medical Research Council of Australia, the National Breast Cancer Foundation, and Cancer Council of Victoria. P.A.B. is supported by a Victorian Cancer Agency Fellowship, and P.K.D. is supported by an NHMRC Senior Research Fellowship (APP1136680).